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Article

Accounting for differential variability in detecting differentially methylated regions.

Briefings in bioinformatics - 18 Jan 2019

Wang Ya, Teschendorff Andrew E, Widschwendter Martin, Wang Shuang

Abstract excerpt

DNA methylation plays an essential role in cancer. Differential variability (DV) in cancer was recently observed that contributes to cancer heterogeneity and has been shown to be crucial in detecting epigenetic field defects, DNA methylation alterations happening early in carcinogenesis. As neighboring CpG sites are highly correlated, here, we present a new method to detect differentially methylated regions...

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PMID: 29912290
DOI: 10.1093/bib/bbx097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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