Accounting for differential variability in detecting differentially methylated regions.

doi:10.1093/bib/bbx097

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Article

Accounting for differential variability in detecting differentially methylated regions.

Briefings in bioinformatics - 18 Jan 2019

Wang Ya, Teschendorff Andrew E, Widschwendter Martin, Wang Shuang

Abstract excerpt

DNA methylation plays an essential role in cancer. Differential variability (DV) in cancer was recently observed that contributes to cancer heterogeneity and has been shown to be crucial in detecting epigenetic field defects, DNA methylation alterations happening early in carcinogenesis. As neighboring CpG sites are highly correlated, here, we present a new method to detect differentially methylated regions...

Topics

Algorithms
Analysis of Variance
Breast Neoplasms
Carcinoma, Renal Cell
Case-Control Studies
Computational Biology
Computer Simulation
CpG Islands
DNA Methylation
DNA, Neoplasm
Databases, Genetic
Epigenesis, Genetic
Female
Genetic Variation
Humans
Kidney Neoplasms
Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 29912290
DOI: 10.1093/bib/bbx097

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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