Article

Deconvolution of DNA methylation signatures identifies common differentially methylated gene regions on 1p36 across breast cancer subtypes

2017-03-16

Abstract excerpt

<h4>ABSTRACT</h4> Breast cancer is a complex disease and studying DNA methylation (DNAm) in tumors is complicated by disease heterogeneity. We compared DNAm in breast tumors with normal-adjacent breast samples from The Cancer Genome Atlas (TCGA). We constructed models stratified by tumor stage and PAM50 molecular subtype and performed cell-type reference-free deconvolution on each model. We identified nineteen di...

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Literature Corpus work: f155278a-acb2-5835-a6a9-e1185a1137eb
DOI: 10.1101/115873

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