Article

DNA methylation variability defines a fundamental dimension of tumor epigenomes linked to genomic instability, tumor aggressiveness, and clinical outcomes

2026-03-14

Abstract excerpt

<h4>Background</h4> Tumors exhibit substantial cellular and molecular diversity driven by genetic and epigenetic mechanisms. Large-scale profiling efforts have established aberrant DNA methylation as a universal hallmark of cancer. Beyond changes in mean methylation levels, tumor tissues exhibit elevated DNA methylation variability at specific genomic regions within and across tumors. This constitutes a fundament...

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Literature Corpus work: db60c1a7-80e6-5a63-baee-fce194719d24
DOI: 10.64898/2026.03.12.711303

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