Article
Extensive intratumor regional epigenetic heterogeneity in clear cell renal cell carcinoma targets kidney enhancers and is associated with poor outcome.
Clinical epigenetics - 29 Apr 2023
El Khoury Louis Y, Pan Xiaoyu, Hlady Ryan A, Wagner Ryan T, Shaikh Shafiq, Wang Liguo, Humphreys Mitchell R, Castle Erik P, Stanton Melissa L, Ho Thai H, Robertson Keith D
Abstract excerpt
BACKGROUND: Clear cell renal cell cancer (ccRCC), the 8th leading cause of cancer-related death in the US, is challenging to treat due to high level intratumoral heterogeneity (ITH) and the paucity of druggable driver mutations. CcRCC is unusual for its high frequency of epigenetic regulator mutations, such as the SETD2 histone H3 lysine 36 trimethylase (H3K36me3), and low frequency of traditional cancer driver...
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