Article

Identifying differentially methylated sites in samples with varying tumor purity

2018-01-16

Abstract excerpt

DNA methylation aberrations are common in many cancer types. A major challenge hindering comparison of patient-derived samples is that they comprise of heterogeneous collection of cancer and microenvironment cells. We present a computational method that allows comparing cancer methylomes in two or more heterogeneous tumor samples featuring differing, unknown fraction of cancer cells. The method is unique in that i...

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Literature Corpus work: de9d79c0-068d-5ce9-b391-28147f685615
DOI: 10.1101/248781

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