Article

DNA methylation variability defines a fundamental dimension of tumor epigenomes linked to genomic instability, tumor aggressiveness, and clinical outcomes

2026-04-30

Abstract excerpt

<title>Abstract</title> <p>Background Tumors exhibit substantial cellular and molecular diversity driven by genetic and epigenetic mechanisms. Large-scale profiling efforts have established aberrant DNA methylation as a universal hallmark of cancer. Beyond changes in mean methylation levels, tumor tissues exhibit elevated DNA methylation variability at specific genomic regions within and across tumors. This cons...

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Literature Corpus work: 87fa29f5-fec7-5ac8-93b1-211d3ac74c42
DOI: 10.21203/rs.3.rs-9393929/v1

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