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Article

Population-level allelic dispersion modeling by maelstRom yields genome-wide maps of allele-specific dysregulation during early carcinogenesis.

GigaScience - 6 Jan 2025

Stroobandt Cedric, Coussement Louis, Goovaerts Tine, De Graeve Femke, Galle Jeroen, Van Criekinge Wim, De Meyer Tim

Abstract excerpt

BACKGROUND: Since its inception, RNA sequencing has been pivotal in studying differential gene expression. Despite its extensive results in large-scale oncological studies, differential expression predominantly reflects a response to cancer. Therefore, we introduce differential allelic dispersion (AD) as a more effective measure. AD highlights consistent differences in expression between the 2 alleles of a gene...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41188181
DOI: 10.1093/gigascience/giaf125
PMCID: PMC12585351

Genes

CCDC8
CLDN7
ECHS1
FBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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