Article
Increased methylation variation in epigenetic domains across cancer types.
Nature genetics - 26 Jun 2011
Hansen Kasper Daniel, Timp Winston, Bravo Héctor Corrada, Sabunciyan Sarven, Langmead Benjamin, McDonald Oliver G, Wen Bo, Wu Hao, Liu Yun, Diep Dinh, Briem Eirikur, Zhang Kun, Irizarry Rafael A, Feinberg Andrew P
Abstract excerpt
Tumor heterogeneity is a major barrier to effective cancer diagnosis and treatment. We recently identified cancer-specific differentially DNA-methylated regions (cDMRs) in colon cancer, which also distinguish normal tissue types from each other, suggesting that these cDMRs might be generalized across cancer types. Here we show stochastic methylation variation of the same cDMRs, distinguishing cancer from normal...
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