Article

Copy number-aware deconvolution of tumor-normal DNA methylation profiles

2020-11-04

Abstract excerpt

<h4>SUMMARY</h4> Aberrant methylation is a hallmark of cancer, but bulk tumor data is confounded by admixed normal cells and copy number changes. Here, we introduce Copy number-Aware Methylation Deconvolution Analysis of Cancers (CAMDAC; https://github.com/VanLoo-lab/CAMDAC ), which outputs tumor purity, allele-specific copy number and deconvolved methylation estimates. We apply CAMDAC to 122 multi-region sample...

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Literature Corpus work: c1e5588c-e462-5fdb-8876-5a841476c319
DOI: 10.1101/2020.11.03.366252

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