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Article

Locally Reducing KCC2 Activity in the Hippocampus is Sufficient to Induce Temporal Lobe Epilepsy.

EBioMedicine - 1 Jun 2018

Kelley Matt R, Cardarelli Ross A, Smalley Joshua L, Ollerhead Thomas A, Andrew Peter M, Brandon Nicholas J, Deeb Tarek Z, Moss Stephen J

Abstract excerpt

Mesial temporal lobe epilepsy (mTLE) is the most common form of epilepsy, believed to arise in part from compromised GABAergic inhibition. The neuronal specific K+/Cl- co-transporter 2 (KCC2) is a critical determinant of the efficacy of GABAergic inhibition and deficits in its activity are observed in mTLE patients and animal models of epilepsy. To test if reductions of KCC2 activity directly contribute to the...

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Identifiers

PMID: 29884458
DOI: 10.1016/j.ebiom.2018.05.029
PMCID: PMC6020795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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