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Article

NKCC1 and KCC2 prevent hyperexcitability in the mouse hippocampus.

Epilepsy research - 1 May 2008

Zhu Lei, Polley Nathan, Mathews Gregory C, Delpire Eric

Abstract excerpt

During postnatal development of the central nervous system (CNS), the response of GABA(A) receptors to its agonist undergoes maturation from depolarizing to hyperpolarizing. This switch in polarity is due to the developmental decrease of the intracellular Cl concentration in neurons. Here we show that absence of NKCC1 in P9-P13 CA3 pyramidal neurons, through genetic manipulation or through bumetanide inhibition,...

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Identifiers

PMID: 18394864
DOI: 10.1016/j.eplepsyres.2008.02.005
PMCID: PMC2394664

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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