Article
KCC2 activity is critical in limiting the onset and severity of status epilepticus.
Proceedings of the National Academy of Sciences of the United States of America - 17 Mar 2015
Silayeva Liliya, Deeb Tarek Z, Hines Rochelle M, Kelley Matt R, Munoz Michaelanne B, Lee Henry H C, Brandon Nicholas J, Dunlop John, Maguire Jaime, Davies Paul A, Moss Stephen J
Abstract excerpt
The K(+)/Cl(-) cotransporter (KCC2) allows adult neurons to maintain low intracellular Cl(-) levels, which are a prerequisite for efficient synaptic inhibition upon activation of γ-aminobutyric acid receptors. Deficits in KCC2 activity are implicated in epileptogenesis, but how increased neuronal activity leads to transporter inactivation is ill defined. In vitro, the activity of KCC2 is potentiated via...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.