Article

Impaired KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathogenesis

2019-04-12

Abstract excerpt

<h4>ABSTRACT</h4> KCC2 is a vital neuronal K + /Cl - co-transporter that is implicated in the etiology of numerous neurological diseases. It is subject to developmental dephosphorylation at threonine 906 and 1007, the functional importance of which remains unclear. We engineered mice with heterozygous phospho-mimetic mutations T906E and T1007E ( KCC2 E/+ ) to prevent the normal developmental dephosphorylation...

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Literature Corpus work: c47241bf-afff-57ef-a502-78a7911a4ebd
DOI: 10.1101/606566

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