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Article

GABAergic disinhibition and impaired KCC2 cotransporter activity underlie tumor-associated epilepsy

26 Jul 2014

Abstract excerpt

Seizures frequently accompany gliomas and often escalate to peritumoral epilepsy. Previous work revealed the importance of tumor-derived excitatory glutamate (Glu) release mediated by the cystine-glutamate transporter (SXC) in epileptogenesis. We now show a novel contribution of GABAergic disinhibition to disease pathophysiology. In a validated mouse glioma model, we found that peritumoral parvalbumin-positive...

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PMID: 25066727
DOI: 10.1002/glia.22730

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