Behavioural phenotypes of hypomorphic KCC2-deficient mice.

doi:10.1111/j.1460-9568.2005.03959.x

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Article

Behavioural phenotypes of hypomorphic KCC2-deficient mice.

The European journal of neuroscience - 1 Mar 2005

Tornberg Janne, Voikar Vootele, Savilahti Harri, Rauvala Heikki, Airaksinen Matti S

Abstract excerpt

Hyperpolarizing fast inhibitory neurotransmission by gamma-aminobutyric acid and glycine requires an efficient chloride extrusion mechanism in postsynaptic neurons. A major effector of this task in adult animals is the potassium-chloride co-transporter KCC2 that is selectively and abundantly expressed postsynaptically in most CNS neurons. Yet, the role of KCC2 in adult brain at the systems level is poorly known....

Topics

Analysis of Variance
Animals
Animals, Newborn
Anticonvulsants
Behavior, Animal
Blotting, Western
Body Weight
Brain
Dose-Response Relationship, Drug
Embryo, Mammalian
Exploratory Behavior
Gene Expression Regulation, Developmental
Maze Learning

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Knockout

Motor Activity

Pain Measurement

Pain Threshold

Source

Open in PubMed

Identifiers

PMID: 15813942
DOI: 10.1111/j.1460-9568.2005.03959.x

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