Article
Deletion of the Na-K-2Cl cotransporter NKCC1 results in a more severe epileptic phenotype in the intrahippocampal kainate mouse model of temporal lobe epilepsy.
Neurobiology of disease - 1 May 2021
Hampel Philip, Johne Marie, Gailus Björn, Vogel Alexandra, Schidlitzki Alina, Gericke Birthe, Töllner Kathrin, Theilmann Wiebke, Käufer Christopher, Römermann Kerstin, Kaila Kai, Löscher Wolfgang
Abstract excerpt
Increased neuronal expression of the Na-K-2Cl cotransporter NKCC1 has been implicated in the generation of seizures and epilepsy. However, conclusions from studies on the NKCC1-specific inhibitor, bumetanide, are equivocal, which is a consequence of the multiple potential cellular targets and poor brain penetration of this drug. Here, we used Nkcc1 knockout (KO) and wildtype (WT) littermate control mice to study...
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