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Article

Restoring neuronal chloride extrusion reverses cognitive decline linked to Alzheimer's disease mutations.

Brain : a journal of neurology - 1 Dec 2023

Keramidis Iason, McAllister Brendan B, Bourbonnais Julien, Wang Feng, Isabel Dominique, Rezaei Edris, Sansonetti Romain, Degagne Phil, Hamel Justin P, Nazari Mojtaba, Inayat Samsoon, Dudley Jordan C, Barbeau Annie, Froux Lionel, Paquet Marie-Eve, Godin Antoine G, Mohajerani Majid H, De Koninck Yves

Abstract excerpt

Disinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading to cognitive deficits. However, the underlying molecular mechanism remains unknown. Here we show that, in mouse lines carrying Alzheimer's disease-related mutations, a loss of neuronal membrane potassium-chloride cotransporter KCC2, responsible for maintaining the robustness of...

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Identifiers

PMID: 37551444
DOI: 10.1093/brain/awad250
PMCID: PMC10690023

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