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Article

KCC2 downregulation facilitates epileptic seizures.

Scientific reports - 13 Mar 2017

Chen Lulan, Wan Li, Wu Zheng, Ren Wanting, Huang Yian, Qian Binbin, Wang Yun

Abstract excerpt

GABAA receptor-mediated inhibition depends on the maintenance of low level intracellular [Cl-] concentration, which in adult depends on neuron specific K+-Cl- cotransporter-2 (KCC2). Previous studies have shown that KCC2 was downregulated in both epileptic patients and various epileptic animal models. However, the temporal relationship between KCC2 downregulation and seizure induction is unclear yet. In this...

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Identifiers

PMID: 28279020
DOI: 10.1038/s41598-017-00196-7
PMCID: PMC5427808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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