Article

Reduced cholecystokinin-expressing interneuron input contributes to disinhibition of the hippocampal CA2 region in a mouse model of temporal lobe epilepsy

2022-11-10

Abstract excerpt

<h4>ABSTRACT</h4> A significant proportion of temporal lobe epilepsy (TLE) patients experience drug-resistant seizures associated with mesial temporal sclerosis, in which there is extensive cell loss in the hippocampal CA1 and CA3 subfields, with a relative sparing of dentate gyrus granule cells and the CA2 pyramidal neurons. A role for CA2 in seizure generation was suggested based on findings of a reduction in s...

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Literature Corpus work: 729ca4c4-f8e0-5489-9b56-79de13ed020e
DOI: 10.1101/2022.11.09.515872

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