Article

Conditional Upregulation of KCC2 selectively enhances neuronal inhibition during seizures

2018-01-25

Abstract excerpt

<h4>Abstract/Summary</h4> Efficacious neuronal inhibition is sustained by the neuronal K + Cl - co-transporter KCC2, and loss of KCC2 function through injury or mutation is associated with altered GABAergic signalling and neuronal seizures. Here we report a transgenic mouse with conditional KCC2 overexpression that results in increased membrane transport function. Increased KCC2 has little impact on behavioural...

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Literature Corpus work: 9c7ff137-b045-59a5-9b04-2de94372eed6
DOI: 10.1101/253831

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