Article
CYP2D6 Genotype Phenotype Discordance Due to Drug-Drug Interaction.
Clinical pharmacology and therapeutics - 1 Nov 2018
Monte Andrew A, West Kelsey, McDaniel Kyle T, Flaten Hania K, Saben Jessica, Shelton Shelby, Abdelmawla Farah, Bushman Lane R, Williamson Kayla, Abbott Diana, Anderson Peter L
Abstract excerpt
Drug-drug interactions have been demonstrated to alter cytochrome 2D6 (CYP2D6) enzyme phenotype due to inhibitor ingestion, although it is unclear how substrate interactions affect phenotype. This was a pragmatic clinical trial examining the kinetics of a CYP2D6 enzyme probe drug with and without CYP2D6-dependent substrates. Patients were enrolled into an inpatient study unit, and orally administered a 2 mg...
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