CYP2D6 genotype and phenotyping by determination of dextromethorphan and metabolites in serum of healthy controls and of patients under psychotropic medication.

doi:10.1097/00008571-199712000-00003

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Article

CYP2D6 genotype and phenotyping by determination of dextromethorphan and metabolites in serum of healthy controls and of patients under psychotropic medication.

Pharmacogenetics - 1 Dec 1997

Köhler D, Härtter S, Fuchs K, Sieghart W, Hiemke C

Abstract excerpt

Fourteen drug free healthy volunteers and 22 psychiatric patients under psychotropic medication were phenotyped for their individual CYP2D6 activity using dextromethorphan as a probe drug. A solution containing 20 mg dextromethorphan was administered and blood was taken 60 min later for determina...

Topics

Adult
Cytochrome P-450 CYP2D6
Dextromethorphan
Female
Genotype
Humans
Male
Middle Aged
Phenotype
Psychotropic Drugs

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