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Article

CYP2D6 pharmacogenetics and phenoconversion in personalized medicine.

Expert opinion on drug metabolism & toxicology - 1 Nov 2022

Nahid Noor A, Johnson Julie A

Abstract excerpt

INTRODUCTION: CYP2D6 contributes to the metabolism of approximately 20-25% of drugs. However, CYP2D6 is highly polymorphic and different alleles can lead to impacts ranging from null to increase in activity. Moreover, there are commonly used drugs that potently inhibit the CYP2D6, thus causing 'phenoconversion' which can convert the genotypic normal metabolizer into phenotypic poor metabolizer. Despite growing...

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Identifiers

PMID: 36597259
DOI: 10.1080/17425255.2022.2160317
PMCID: PMC9891304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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