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Article

Substrate specificity of CYP2D6 genetic variants.

Pharmacogenomics - 1 Nov 2021

van der Lee Maaike, Guchelaar Henk-Jan, Swen Jesse J

Abstract excerpt

Genetic variation in the gene encoding CYP2D6 is used to guide drug prescribing in clinical practice. However, genetic variants in CYP2D6 show substrate-specific effects that are currently not accounted for. With a systematic literature, we retrieved 22 original studies describing in vitro experiments focusing on CYP2D6 alleles (CYP2D6*1, *2, *10 and *17) and substrates. Allele activity (clearance of the allele...

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Identifiers

PMID: 34569808
DOI: 10.2217/pgs-2021-0093

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