Article

Physiologically based pharmacokinetic (PBPK) modeling of the role of CYP2D6 polymorphism for metabolic phenotyping with dextromethorphan

2022-08-25

Abstract excerpt

<h4>ABSTRACT</h4> The cytochrome P450 2D6 (CYP2D6) is a key xenobiotic-metabolizing enzyme involved in the clearance of many drugs. Genetic polymorphisms in CYP2D6 contribute to the large inter-individual variability in drug metabolism and could affect metabolic phenotyping of CYP2D6 probe substances such as dextromethorphan (DXM). To study this question, we (i) established an extensive pharmacokinetics dataset f...

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Literature Corpus work: 3ef7e4a6-4cfd-5923-bc60-5d90450b896e
DOI: 10.1101/2022.08.23.504981

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