Article
CYP2D6 Allelic Variants *34, *17-2, *17-3, and *53 and a Thr309Ala Mutant Display Altered Kinetics and NADPH Coupling in Metabolism of Bufuralol and Dextromethorphan and Altered Susceptibility to Inactivation by SCH 66712.
Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2018
Glass Sarah M, Martell Cydney M, Oswalt Alexandria K, Osorio-Vasquez Victoria, Cho Christi, Hicks Michael J, Mills Jacqueline M, Fujiwara Rina, Glista Michael J, Kamath Sharat S, Furge Laura Lowe
Abstract excerpt
Metabolic phenotype can be affected by multiple factors, including allelic variation and interactions with inhibitors. Human CYP2D6 is responsible for approximately 20% of cytochrome P450-mediated drug metabolism but consists of more than 100 known variants; several variants are commonly found in the population, whereas others are quite rare. Four CYP2D6 allelic variants-three with a series of mutations distal to...
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