Article
Concordance of P450 2D6 (debrisoquine hydroxylase) phenotype and genotype: inability of dextromethorphan metabolic ratio to discriminate reliably heterozygous and homozygous extensive metabolizers.
Pharmacogenetics - 1 Dec 1991
Evans W E, Relling M V
Abstract excerpt
Debrisoquine-hydroxylase (P450 2D6) not equal to phenotype was determined in 116 individuals using dextromethorphan as the substrate probe. Polymerase chain reaction and restriction fragment length polymorphism analyses were used to detect inactivating mutations in the CYP2D6 gene and assign geno...
Topics
- Adolescent
- Adult
- Alleles
- Child
- Child, Preschool
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Dextromethorphan
- Female
- Genetic Variation
- Genotype
- Heterozygote
- Homozygote
- Humans
- Male
- Middle Aged
- Mixed Function Oxygenases
- Mutation