Article
In vivo characterization of CYP2D6*12, *29 and *84 using dextromethorphan as a probe drug: a case report.
Pharmacogenomics - 1 Apr 2017
Gaedigk Andrea, Twist Greyson P, Farrow Emily G, Lowry Jennifer A, Soden Sarah E, Miller Neil A
Abstract excerpt
CYP2D6*84 was first described in a Black South African subject, however, its function remains unknown. Astrolabe, a probabilistic scoring tool developed in our laboratory to call genotypes from whole genome sequence, identified CYP2D6*84 in a trio. The father presented with intermediate metabolism when challenged with the CYP2D6 probe drug dextromethorphan (DM/dextrorphan [DX] = 0.0839). Since his second allele,...
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