Article
Autoantibody production in Sjögren's syndrome: a hypothesis regarding defects in somatic diversification of germ line encoded genes.
In vivo (Athens, Greece) - 1 Jan 2000
Fox R I, Fong S, Chen P P, Kipps T J
Abstract excerpt
Patients with primary Sjögren's syndrome (SS) have rheumatoid factor (anti-IgG Fc antibody, RF) in their sera that contains a crossreactive idiotype (CRI) defined by monoclonal antibody 17-109. This CRI is shared by SS patients and certain patients with Waldenstrom's macroglobulinemia. This CRI was not found in increased frequency in RF from rheumatoid arthritis patients lacking SS. The structural basis for this...
Topics
- Amino Acid Sequence
- Autoantibodies
- B-Lymphocytes
- Base Sequence
- Genes, Immunoglobulin
- Genetic Variation
- Humans
- Immunoglobulin Idiotypes
- Models, Biological
- Molecular Sequence Data
- Mutation