Article
Diversification of sheep immunoglobulins.
Veterinary immunology and immunopathology - 15 Dec 1999
Hein W R, Dudler L
Abstract excerpt
The sheep antibody repertoire was assessed by sequence analysis of Vlambda Vkappa and V(H) cDNA clones. In fetuses, all immunoglobulin chains were essentially in germline configuration, although limited diversity occurred at the junctional regions of Vkappa chains. Fetal B cells expressed 12 distinct Vlambda and six Vkappa gene segments. V(H) gene segments were also in germline configuration in fetuses but became...
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