Article
Analysis of immunoglobulin E V<sub>H</sub> transcripts in a bronchial biopsy of an asthmatic patient confirms bias towards V<sub>H</sub>5, and indicates local clonal expansion, somatic mutation and isotype switch events
1 Dec 1999
Abstract excerpt
Immunoglobulin E (IgE)-dependent mechanisms play a pivotal role in mediating allergic disease. Previously, VH-Cepsilon transcripts from blood or spleen of atopic asthmatics have been analysed for VH gene usage and patterns of somatic mutation. An over-representation of the minor VH5 family has been observed, consistent with a superantigen drive. As local mucosal events in IgE production may be more significant in...
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