Article
Cationic residues in pathogenic anti-DNA autoantibodies arise by mutations of a germ-line gene that belongs to a large VH gene subfamily.
European journal of immunology - 1 Mar 1992
O'Keefe T L, Datta S K, Imanishi-Kari T
Abstract excerpt
The F1 progeny of autoimmune NZB and normal SWR mice uniformly develop severe and accelerated lupus nephritis. The (SWR x NZB)F1 mice produce an oligoclonally expanded population of nephritogenic anti-DNA autoantibodies that share a recurrent cross-reactive idiotype (Id564), use highly homologous...
Topics
- Amino Acid Sequence
- Animals
- Antibodies, Antinuclear
- Base Sequence
- Genes, Immunoglobulin
- Immunoglobulin Heavy Chains
- Immunoglobulin Variable Region
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic