Targeting of human switch recombination breakpoints: implications for the mechanism of mu-gamma isotype switching.

doi:10.1002/(SICI)1521-4141(199909)29:09<2779::AID-IMMU2779>3.0.CO;2-0

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Article

Targeting of human switch recombination breakpoints: implications for the mechanism of mu-gamma isotype switching.

European journal of immunology - 1 Sept 1999

Pan Q, Hammarström L

Abstract excerpt

We recently characterized the allelic variants of the human Sgamma4 region which makes it possible to accurately identity and map Smu-Sgamma4 fragments from in vivo switched B cells. Twenty-six fragments were identified and a comparison was made with all previously published Smu-Sgamma sequences ( n = 82). Switch recombination outside the region flanking the Sgamma repeat sequence is a rare event in vivo and...

Topics

Alleles
Blotting, Southern
Chromosome Mapping
DNA
DNA Mutational Analysis
Gene Amplification
Gene Rearrangement, B-Lymphocyte
Humans
Immunoglobulin Class Switching
Immunoglobulin gamma-Chains
Immunoglobulin mu-Chains
Mutagenesis
Mutation
Polymorphism, Restriction Fragment Length
Repetitive Sequences, Nucleic Acid

Source

Open in PubMed

Identifiers

PMID: 10508252
DOI: 10.1002/(SICI)1521-4141(199909)29:09<2779::AID-IMMU2779>3.0.CO;2-0

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