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Article

Somatic hypermutation of immunoglobulin genes in human neonates.

Clinical and experimental immunology - 1 May 1997

Ridings J, Nicholson I C, Goldsworthy W, Haslam R, Roberton D M, Zola H

Abstract excerpt

The antibody response in the young infant is limited in several ways; in particular, responses generally are of low affinity and restricted to IgM. This raises the question whether the affinity maturation process, consisting of somatic mutation of immunoglobulin genes coupled with selection of high-affinity variants, is operative in the neonate. Re-arranged V(H)6 genes were amplified by polymerase chain reaction...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9158112
DOI: 10.1046/j.1365-2249.1997.3631264.x
PMCID: PMC1904651

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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