Somatic hypermutation of immunoglobulin genes in human neonates.

doi:10.1046/j.1365-2249.1997.3631264.x

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Article

Somatic hypermutation of immunoglobulin genes in human neonates.

Clinical and experimental immunology - 1 May 1997

Ridings J, Nicholson I C, Goldsworthy W, Haslam R, Roberton D M, Zola H

Abstract excerpt

The antibody response in the young infant is limited in several ways; in particular, responses generally are of low affinity and restricted to IgM. This raises the question whether the affinity maturation process, consisting of somatic mutation of immunoglobulin genes coupled with selection of hi...

Topics

Amino Acid Sequence
Base Sequence
Cloning, Molecular
Fetal Blood
Genes, Immunoglobulin
Humans
Immunoglobulin Variable Region
Infant
Infant, Newborn
Molecular Sequence Data
Mutation
Nucleic Acid Heteroduplexes
Sequence Analysis, DNA

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