Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunoglobulin Vkappa light chain gene analysis in patients with Sjögren's syndrome.

Arthritis and rheumatism - 1 Mar 2001

Heimbächer C, Hansen A, Pruss A, Jacobi A, Reiter K, Lipsky P E, Dörner T

Abstract excerpt

OBJECTIVE: Patients with Sjögren's syndrome (SS) have characteristic lymphocytic infiltration of the salivary glands with a previously reported predominance of Vkappa-bearing B cells and produce a variety of autoantibodies, indicating that there is a humoral autoimmune component in this syndrome. This study was undertaken to determine whether there are primary deviations of immunoglobulin V gene usage,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to B-Lymphocytes
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Amplification

Share to Gene Rearrangement, B-Lymphocyte, Light Chain

Share to Polymerase Chain Reaction

Share to Repetitive Sequences, Nucleic Acid

Share to Sjogren's Syndrome

Source

Identifiers

PMID: 11263777
DOI: 10.1002/1529-0131(200103)44:3<626::AID-ANR111>3.0.CO;2-T

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunoglobulin Vkappa light chain gene analysis in patients with Sjögren's syndrome.PMID 11263777Read ↗

Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome.Semantic proximity Read ↗

Somatic hypermutation of VkappaJkappa rearrangements: targeting of RGYW motifs on both DNA strands and preferential selection of mutated codons within RGYW motifs.Semantic proximity Read ↗

Enhanced mutational activity of Vkappa gene rearrangements in systemic lupus erythematosus.Semantic proximity Read ↗

Immunoglobulin kappa chain receptor editing in systemic lupus erythematosus.Semantic proximity Read ↗

Autoantibody production in Sjögren's syndrome: a hypothesis regarding defects in somatic diversification of germ line encoded genes.Semantic proximity Read ↗

Salivary gland lymphomas in patients with Sjögren's syndrome may frequently develop from rheumatoid factor B cells.Semantic proximity Read ↗

Enhanced mutational activity and disturbed selection of mutations in V(H) gene rearrangements in a patient with systemic lupus erythematosus.Semantic proximity Read ↗

The normally expressed kappa immunoglobulin light chain gene repertoire and somatic mutations studied by single-sided specific polymerase chain reaction (PCR); frequent occurrence of features often assigned to autoimmunity.Semantic proximity Read ↗

Analysis of VH-D-JH gene transcripts in B cells infiltrating the salivary glands and lymph node tissues of patients with Sj�gren's syndromeSemantic proximity Read ↗

Rheumatoid factors in primary Sjögren's syndrome (pSS) use diverse VH region genes, the majority of which show no evidence of somatic hypermutation.Semantic proximity Read ↗

The role of CD40-CD40 ligand (CD154) interactions in immunoglobulin light chain repertoire generation and somatic mutation.Semantic proximity Read ↗

Genomic absence of the gene encoding T cell receptor Vbeta7.2 is linked to the presence of autoantibodies in Sjögren's syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.