Article
JCAD, a Gene at the 10p11 Coronary Artery Disease Locus, Regulates Hippo Signaling in Endothelial Cells.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2018
Jones Peter D, Kaiser Michael A, Ghaderi Najafabadi Maryam, Koplev Simon, Zhao Yuqi, Douglas Gillian, Kyriakou Theodosios, Andrews Sarah, Rajmohan Rathinasabapathy, Watkins Hugh, Channon Keith M, Ye Shu, Yang Xia, Björkegren Johan L M, Samani Nilesh J, Webb Tom R
Abstract excerpt
Objective- A large number of genetic loci have been associated with risk of coronary artery disease (CAD) through genome-wide association studies, however, for most loci the underlying biological mechanism is unknown. Determining the molecular pathways and cellular processes affected by these loci will provide new insights into CAD pathophysiology and may lead to new therapies. The CAD-associated variants at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.