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Article

Common Coronary Artery Disease Risk Variants in Endothelial Regulatory Elements Modulate Tetraspanin 14 Expression and Notch Signaling.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2026

Lee-Kim Vivian S, Schnitzler Gavin R, Fang Shi, Mardani-Kamali Neeka, Cai Xiangmeng Shawn, Cui Ran, Barry Aurelie E, Zandavi Miad, Yoo Hyung-Jin, Kant Shashi, Mahajan Ragini, Rao Suhas S P, Aiden Erez Lieberman, Engreitz Jesse M, Gupta Rajat M

Abstract excerpt

BACKGROUND: Coronary artery disease (CAD) is a complex condition and remains the leading cause of mortality worldwide. Genome-wide association studies have identified a CAD risk locus on chromosome 10q23 that is independent of traditional risk factors, providing an opportunity to uncover novel molecular mechanisms contributing to CAD pathogenesis. METHODS: Improved fine-mapping approaches were used to prioritize...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42021732
DOI: 10.1161/ATVBAHA.125.323330
PMCID: PMC13148780

Genes

TSPAN14
CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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