Article
Targeted Disruption of JCAD (Junctional Protein Associated With Coronary Artery Disease)/KIAA1462, a Coronary Artery Disease-Associated Gene Product, Inhibits Angiogenic Processes In Vitro and In Vivo.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2017
Hara Tetsuya, Monguchi Tomoko, Iwamoto Noriko, Akashi Masaya, Mori Kenta, Oshita Toshihiko, Okano Mitsumasa, Toh Ryuji, Irino Yasuhiro, Shinohara Masakazu, Yamashita Yui, Shioi Go, Furuse Mikio, Ishida Tatsuro, Hirata Ken-Ichi
Abstract excerpt
OBJECTIVE: Recent genome-wide association studies newly identified the human KIAA1462 gene as a new locus for coronary artery disease. However, the function of the gene product, named JCAD (junctional protein associated with coronary artery disease), is unknown. Because JCAD is expressed at cell-cell junctions in endothelial cells, we hypothesized and tested whether JCAD regulates angiogenic processes in vitro...
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