Convergence of coronary artery disease genes onto endothelial cell programs.

doi:10.1038/s41586-024-07022-x

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Article

Convergence of coronary artery disease genes onto endothelial cell programs.

Nature - 1 Feb 2024

Schnitzler Gavin R, Kang Helen, Fang Shi, Angom Ramcharan S, Lee-Kim Vivian S, Ma X Rosa, Zhou Ronghao, Zeng Tony, Guo Katherine, Taylor Martin S, Vellarikkal Shamsudheen K, Barry Aurelie E, Sias-Garcia Oscar, Bloemendal Alex, Munson Glen, Guckelberger Philine, Nguyen Tung H, Bergman Drew T, Hinshaw Stephen, Cheng Nathan, Cleary Brian, Aragam Krishna, Lander Eric S, Finucane Hilary K, Mukhopadhyay Debabrata, Gupta Rajat M, Engreitz Jesse M

Abstract excerpt

Linking variants from genome-wide association studies (GWAS) to underlying mechanisms of disease remains a challenge1-3. For some diseases, a successful strategy has been to look for cases in which multiple GWAS loci contain genes that act in the same biological pathway1-6. However, our knowledge of which genes act in which pathways is incomplete, particularly for cell-type-specific pathways or understudied...

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Identifiers

PMID: 38326615
DOI: 10.1038/s41586-024-07022-x
PMCID: PMC10921916

Genes

CAD
TLNRD1
CCM2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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