Article
Genome-wide linkage scan identifies two novel genetic loci for coronary artery disease: in GeneQuest families.
PloS one - 1 Jan 2014
Gao Hanxiang, Li Lin, Rao Shaoqi, Shen Gongqing, Xi Quansheng, Chen Shenghan, Zhang Zheng, Wang Kai, Ellis Stephen G, Chen Qiuyun, Topol Eric J, Wang Qing K
Abstract excerpt
Coronary artery disease (CAD) is the leading cause of death worldwide. Recent genome-wide association studies (GWAS) identified >50 common variants associated with CAD or its complication myocardial infarction (MI), but collectively they account for <20% of heritability, generating a phenomena of "missing heritability". Rare variants with large effects may account for a large portion of missing heritability....
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