Article
Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases.
PLoS genetics - 1 Jan 2020
Nurnberg Sylvia T, Guerraty Marie A, Wirka Robert C, Rao H Shanker, Pjanic Milos, Norton Scott, Serrano Felipe, Perisic Ljubica, Elwyn Susannah, Pluta John, Zhao Wei, Testa Stephanie, Park YoSon, Nguyen Trieu, Ko Yi-An, Wang Ting, Hedin Ulf, Sinha Sanjay, Barash Yoseph, Brown Christopher D, Quertermous Thomas, Rader Daniel J
Abstract excerpt
Genome-wide association studies have identified multiple novel genomic loci associated with vascular diseases. Many of these loci are common non-coding variants that affect the expression of disease-relevant genes within coronary vascular cells. To identify such genes on a genome-wide level, we performed deep transcriptomic analysis of genotyped primary human coronary artery smooth muscle cells (HCASMCs) and...
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