Article
Genome-Wide Association and Functional Studies Identify SCML4 and THSD7A as Novel Susceptibility Genes for Coronary Artery Disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2018
Li Yang, Wang Dao Wen, Chen Yundai, Chen Can, Guo Jian, Zhang Shu, Sun Zhijun, Ding Hu, Yao Yan, Zhou Lei, Xu Ke, Song Chun, Yang Fan, Zhao Bin, Yan Han, Wang Wen-Jing, Wu Chong, Lu Xiangfeng, Yang Xueli, Dong Jie, Zheng Guyan, Tian Shuhan, Cui Yanjun, Jin Lijuan, Liu Gangqiong, Cui Hanbin, Wang Shenghuang, Jiang Feng, Wang Changhua, Erdmann Jeanette, Zeng Linyao, Huang Shian, Zhong Jianfeng, Ma Yuehua, Chen Wenjiang, Sun Jianli, Lei Wei, Chen Shenghan, Rao Shaoqi, Gu Dongfeng, Schunkert Heribert, Tian Xiao-Li
Abstract excerpt
OBJECTIVE: The genetic contribution to coronary artery disease (CAD) remains largely unclear. We combined genetic screening with functional characterizations to identify novel loci and candidate genes for CAD. APPROACH AND RESULTS: We performed genome-wide screening followed by multicenter validation in 8 cohorts consisting of 21 828 participants of Han ethnicity and identified 3 novel intragenic SNPs (single...
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