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Antiviral Mechanism and Biochemical Basis of the Human APOBEC3 Family

1 Jan 2012

Abstract excerpt

The human APOBEC3 (A3) family (A, B, C, DE, F, G, and H) comprises host defense factors that potently inhibit the replication of diverse retroviruses, retrotransposons, and the other viral pathogens. HIV-1 has a counterstrategy that includes expressing the Vif protein to abrogate A3 antiviral function. Without Vif, A3 proteins, particularly APOBEC3G (A3G) and APOBEC3F (A3F), inhibit HIV-1 replication by blocking...

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PMID: 22787460
DOI: 10.3389/fmicb.2012.00250

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