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Article

DNA methylation in the APOE genomic region is associated with cognitive function in African Americans.

BMC medical genomics - 8 May 2018

Liu Jiaxuan, Zhao Wei, Ware Erin B, Turner Stephen T, Mosley Thomas H, Smith Jennifer A

Abstract excerpt

BACKGROUND: Genetic variations in apolipoprotein E (APOE) and proximal genes (PVRL2, TOMM40, and APOC1) are associated with cognitive function and dementia, particularly Alzheimer's disease. Epigenetic mechanisms such as DNA methylation play a central role in the regulation of gene expression. Recent studies have found evidence that DNA methylation may contribute to the pathogenesis of dementia, but its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29739406
DOI: 10.1186/s12920-018-0363-9
PMCID: PMC5941603

Genes

APOE
TOMM40
APOC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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