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Apolipoprotein E DNA methylation and late-life disease

7 Feb 2018

Abstract excerpt

BACKGROUND: This study aims to investigate if DNA methylation of the apolipoprotein E (APOE) locus affects the risks of dementia, Alzheimeŕs disease (AD) or cardiovascular disease (CVD). METHODS: DNA methylation across the APOE gene has previously been categorized into three distinct regions: a hypermethylated region in the promoter, a hypomethylated region in the first two introns and exons and a hypermethylated...

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PMID: 29509901
DOI: 10.1093/ije/dyy025

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