DNA methylation signature of cognitive reserve moderates CSF tau pathology in prodromal Alzheimer’s disease

Abstract excerpt

<title>Abstract</title> <p> <bold>Background</bold> Cognitive reserve (CR) refers to differences in the adaptability of cognitive processes that modify the impact of Alzheimer’s disease (AD) pathology on cognitive performance. Currently there are no established blood-based biomarkers of CR in prodromal AD. In this study, we operationalize CR as memory reserve, defined as moderation (attenuation) of the CSF pTau...

Topics

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• Apolipoprotein C-I
• Black or African American
• Cognition
• CpG Islands
• Educational Status
• Mental Recall
• Mitochondrial Precursor Protein Import Complex Proteins
• Nectins

Identifiers and source

Literature Corpus work

7a9b2094-b1a0-5293-a299-e657a22b8e03

DOI

10.21203/rs.3.rs-8369919/v1