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Article

DNA methylation of TOMM40-APOE-APOC2 in Alzheimer's disease.

Journal of human genetics - 1 Apr 2018

Shao Yvonne, Shaw McKenzie, Todd Kaitlin, Khrestian Maria, D'Aleo Giana, Barnard P John, Zahratka Jeff, Pillai Jagan, Yu Chang-En, Keene C Dirk, Leverenz James B, Bekris Lynn M

Abstract excerpt

The apolipoprotein E (APOE) ε4 allele is the major genetic risk factor for Alzheimer's disease (AD). Multiple regulatory elements, spanning the extended TOMM40-APOE-APOC2 region, regulate gene expression at this locus. Regulatory element DNA methylation changes occur under different environmental conditions, such as disease. Our group and others have described an APOE CpG island as hypomethylated in AD, compared...

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Identifiers

PMID: 29371683
DOI: 10.1038/s10038-017-0393-8
PMCID: PMC6466631

Genes

APOE
TOMM40
APOC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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