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Article

APOE gene region methylation is associated with cognitive performance in middle-aged urban adults.

Neurobiology of aging - 1 Aug 2022

Shen Botong, Hernandez Dena G, Chitrala Kumaraswamy Naidu, Fanelli-Kuczmarski Marie T, Noren Hooten Nicole, Pacheco Natasha L, Mode Nicolle A, Zonderman Alan B, Ezike Ngozi, Evans Michele K

Abstract excerpt

Apolipoprotein (APOE) ε4 allele is a strong risk factor for Alzheimer's disease (AD) and cognitive decline. Epigenetic modifications such as DNA methylation (DNAm) play a central role in cognition. This study sought to identify DNAm sites in the APOE genomic region associated with cognitive performance in a racially diverse middle-aged cohort (n = 411). Cognitive performance was measured by 11 standard...

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Identifiers

PMID: 35561457
DOI: 10.1016/j.neurobiolaging.2022.03.010
PMCID: PMC10878469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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