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Blood-based epigenome-wide analyses of cognitive abilities

17 Jan 2022

Abstract excerpt

BACKGROUND: Blood-based markers of cognitive functioning might provide an accessible way to track neurodegeneration years prior to clinical manifestation of cognitive impairment and dementia. RESULTS: Using blood-based epigenome-wide analyses of general cognitive function, we show that individual differences in DNA methylation (DNAm) explain 35.0% of the variance in general cognitive function (g). A DNAm...

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PMID: 35039062
DOI: 10.1186/s13059-021-02596-5

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