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Article

Genetic interaction between Gli3 and Ezh2 during limb pattern formation.

Mechanisms of development - 1 Jun 2018

Deimling Steven J, Lau Kimberly, Hui Chi-Chung, Hopyan Sevan

Abstract excerpt

Anteroposterior polarity of the early limb bud is essential for proper skeletal pattern formation. In order to establish anterior identity, hedgehog signalling needs to be repressed by GLI3 repressor activity, although the mechanism of repression is not well defined. Here we describe genetic interaction between Gli3 and Enhancer of Zeste 2 (Ezh2) that encodes the histone methyltransferase subunit of Polycomb...

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Source

Identifiers

PMID: 29729398
DOI: 10.1016/j.mod.2018.05.002

Genes

GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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